Issoufou Amadou 
,
Guo-Wei Le,
Yong-Hui Shi
For correspondence:- Issoufou Amadou Email: issoufsara@gmail.com Tel:+8651085917789
Received: 23 October 2011 Accepted: 24 March 2012 Published: 15 June 2012
Citation: Amadou I, Le G, Shi Y. Effect of Boiling on the Cytotoxic and Antioxidant Properties of Aqueous Fruit Extract of Desert Date, Balanites aegyptiaca (L) Delile. Trop J Pharm Res 2012; 11(3):437-444 doi: 10.4314/tjpr.v11i3.13
© 2012 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the effect of boiling on in vitro bioactivities potency of Balanites aegyptiaca L. Delile (desert date) aqueous extract, a juice used traditionally for cooking ready-to-eat millet flour paste.
Methods: Desert date fruits (1.5 kg) were soaked in water (1:2, fruit: water) for 24 h and sieved. The extract was divided into two parts - fresh extract (Fext) and boiled extract (Bext) which was obtained by boiling a portion of Fext for 10 min. The extracts were tested against the stomach cancer cell line SGC7901 and for antioxidant activity by 1,1-diphenyl-2-icrylhydrazyl DPPH, hydroxyl radical and ferric reducing power methods.
Results: Both fresh extract (Fext) and boiled extract (Bext) exhibited pronounced antioxidant activity with DPPH values of 88.2 and 97.0 %, respectively, at hydroxyl radical concentration of 5 mg/ml. The extract contained a significant amount of vitamin C (42.3 and 38.9 mg/100 g for Fext and Bext, respectively). Boiling had significant effect (p < 0.01) on its antioxidant activity and also on its cytotoxic effect (56 % and 44 % dead cells respectively for Bext and Fext at respectively, at a concentration of 200 μg/ml).
Conclusion: It is concluded that B. aegyptiaca aqueous extracts have remarkable cytotoxic activity against stomach cancer cell SGC7901.
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